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We pooled IPD from 22 randomized controlled trials (RCTs), with in total more than 4000 patients for our analyses.
Overall, we found clear evidence that psychosocial interventions significantly improve quality of life as well as emotional and social function in patients with cancer, with largest effects for psychotherapy. We found evidence that effects of coping skills training were moderated by age, treatment type, and targeted interventions. We found some evidence that effects of psychotherapy on emotional function may be moderated by cancer type, but these analyses were based on few studies.